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In this phase 2 clinical trial, plx3397 at a dose of 900 mg/day showed limited activity in this heavily pretreated patient cohort Blockade of csf1r activity using the tyrosine kinase inhibitor plx3397 limited the expression of genes associated with innate immunity and decreased levels of circulating. However, target inhibition of both fms and kit.
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To determine whether a high dose of plx3397 impacts peripheral myeloid and lymphoid cell numbers in the homeostatic state, we quantified different populations of immune cells in the. Male mice exhibited greater microglial depletion. Plx3397 was recently approved by the food and drug administration (fda) to treat tenosynovial giant cell tumor and reprogram tams whose infiltration correlates with.
